A teenager dies under questionable circumstances, rocking the lives of residents in a small Florida town. Another teen, held responsible for the death, commits suicide. Not Without Anna, shows how the town and families cope with the tragic deaths to become a closer, more involved community that truly cares enough about its children and their future to take control and fight back.

Rookie Detective, Karen Sykes, is out to proves she is good at at her job, finding justice for the darkness in her past through law enforcement. She gets her first chance to shine with a case that hits a little too close to home. Like her younger sister, a four-year-old boy, has been brutally murdered. The case pairs her with Mike Connelly, an attractive crime scene technician, and sparks fly between the two of them. Mike resists the attraction and only adds more emotional conflict to the case.

When her partner becomes the latest victim and ends up in the hospital near death, Karen sets out to find the murderer before her hurts anyone else. Only the case gets trickier when the murder suspect ends up dead, leaving new clues to the real killer. Finding comfort in Mike's support, their relationship heats up, but so does the investigation. The killer has a plan. One that involves a Cat and Mouse game of hide and seek inside the hospital, where her partner struggles for his life. Karen discovers it takes more than catching a killer to make the pain of her past go away. It also takes opening her heart and learning to trust in others.